浙江农林大学博士生导师简介动物科技学院(动物医学院)-宋厚辉

宋厚辉 教授，博士生导师，浙江农林大学副校长、校党委委员，动物科技学院·动物医学院院长。浙江省第五届师德先进个人，浙江省人才专项，浙江省中青年学科带头人。动物健康检测互联网技术浙江省工程研究中心主任，浙江省畜禽绿色生态健康养殖应用技术研究重点实验室主任，浙江省动物医学与健康管理国际科技合作基地主任。主要从事动物预防医学和兽医公共卫生学研究。兼任中国兽医协会动物福利分会会长，中国畜牧兽医学会兽医食品卫生学分会副理事长，浙江省畜牧兽医学会副理事长, 教育部动物医学类专业教学指导委员会委员，浙江省高等学校农林类专业教学指导委员会委员。动物医学国家一流专业建设点负责人，国家一流课程负责人。目前已经发表学术论文300余篇；授权专利20余件，主编教材（著作）4部，参编专著（教材）10部。

实验室网站：http://www.listeria.cn

通讯地址

浙江省杭州市临安区武肃街666号，浙江农林大学动物科技学院，学二109房间

邮编：311300

E-mail:songhh@zafu.edu.cn

电话/传真：0571-63741392

教育背景

博士 (2002/09/01-2005/03/26): 中国科学院微生物研究所

硕士 (1999/09/01-2002/06/30): 浙江大学动物科学学院

学士(1995/09/01-1999/07/07):莱阳农学院（现为青岛农业大学）动物科学系

工作经历

2020/08-至今：浙江农林大学党委委员

2016/07/12- 至今：浙江农林大学动物科技学院·动物医学院 院长

2013/04 -2016/07：浙江农林大学动物科技学院、农业与食品科学学院  副院长

2011/11 - 至今：浙江农林大学动物科技学院·动物医学院 教师、研究员、教授

2011/05 - 2011/11：美国西雅图生物医学研究所  助理研究员

2010/05 - 2011/05：美国阿拉巴马大学（伯明翰校区）微生物系  高级博士后研究员

2008/05 - 2010/11：中国科学院青岛生物能源与过程研究所  副研究员

2005/06 - 2008/05：美国阿拉巴马大学（伯明翰校区）微生物系 博士后

科研项目（部分）

1. 畜禽食源性病原综合防控技术体系构建与应用示范，国家重点研发计划课题，2023YFD1801005, 430万元，2023.12-2027.12

2. 单增李斯特菌谷氧还蛋白Grx介导的氧化应激耐受及感染机制研究，国家自然科学基金面上项目，31972648，58 万元，2020.01-2023.12

3. 单核细胞增多性李斯特菌二硫键形成蛋白DsbA对氧化应激、鞭毛合成和毒力的调控机制研究, 国家自然科学基金面上项目 ，31770040, 65 万元，2018.1-2021.12

4. 浙江省自然科学基金重点项目，单核细胞增多性李斯特菌YjbH介导的抗应激和感染生物学机制研究，LZ19C180001，2019.01-2022.12, 35万元

5. 科技部国家重点研发计划，重大动物源性病原体传入风险评估和预警技术研究，2017YFC1200500, 95万元，2017.7 -2020.06

研究方向

动物预防医学和兽医公共卫生

发表论文（部分）

1. Wang J, Cui M, Liu Y, Chen M, Xu J, Xia J, Sun J, Jiang L, Fang W, Song* H, Cheng* C. The mitochondrial carboxylase PCCA interacts with Listeria monocytogenes phospholipase PlcB to modulate bacterial survival. Appl Environ Microbiol. 2024 Jun 18;90(6):e0213523.

2. Li Y, Song J, Jiang S, Yang Y, Han Y, Zhong L, Zhou J, Wang M, Song* H, Xu* Y. Canine distemper virus (CDV)-neutralizing activities of an anti-CDV canine-derived single-chain variable antibody fragment 4-15 (scFv 4-15) screened by phage display technology. Int J Biol Macromol. 2024 Feb;257(Pt 2):128645.

3. Shan X, Li R, Ma X, Qiu G, Xiang Y, Zhang X, Wu D, Wang L, Zhang J, Wang T, Li W, Xiang* Y, Song* H, Niu* D. Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus. Funct Integr Genomics. 2024 Apr 24;24(3):79.

4. Ge Z, Xu J, Yang K, Wu L, Chen S, Chen B, Tian J, Zhang J, Xu A, Huang B, Song* H, Yang* Y. Molecular mechanism of bovine Gasdermin D-mediated pyroptosis. Vet Res. 2024 Feb 27;55(1):26

5. Dong W, Cheng Y, Zhou Y, Zhang J, Yu X, Guan H, Du J, Zhou X, Yang Y, Fang W, Wang* X, Song* H. The nucleocapsid protein facilitates p53 ubiquitination-dependent proteasomal degradation via recruiting host ubiquitin ligase COP1 in PEDV infection. J Biol Chem. 2024 Mar 4:107135

6. Xu A, Yang K, Xu J, Meng X, Liang Q, Huang B, Yang* Y, Song* H. Mycobacterial PE12 protein promotes bacterial survival through inhibiting cell apoptosis. Vet Microbiol. 2024 288:109922.

7. Deng S, Liao J, Li H, Xu J, Fan J, Xia J, Wang J, Lei L, Chen M, Han Y, Zhai R, Zhou C, Zhou R, Cheng* C, Song* H. Streptococcus suis subtilisin-like serine proteases SspA-1 and SspA-2 interplay with complement C3a and C5a to facilitate bacterial immune evasion and infection. Virulence. 2024;15(1):2301246

8. Yifan Niu, Yu Liu, Xiang Ma, Lu Liu, Sihong Li, Rui Li, Tao Wang*, Houhui Song*, Dong Niu*, Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice, Mucosal Immunology, 2024;17(1),54-66

9. Liu M, Cho WC, Flynn RJ, Jin X, Song* H, Zheng* Y. microRNAs in parasite-induced liver fibrosis: from mechanisms to diagnostics and therapeutics. Trends Parasitol. 2023 Oct;39(10):859-872.

10. Li H, Liu T, Yang Y, Cho WC, Flynn RJ, Harandi MF, Song* H, Luo* X, Zheng* Y. Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy. Genes Dis. 2022 Sep 5;10(4):1457-1469

11. Wang J, He Z, Cui M, Sun J, Jiang L, Zhuang N, Zhu F, Zhang X, Song* H, Cheng* C. Hypoxia-induced HIF-1α promotes Listeria monocytogenes invasion into tilapia. Microbiol Spectr. 2023 Sep 8;11(5):e0140523

12. Yan L, Li Y, Li R, Liu M, He X, Yang X, Cho WC, Ayaz M, Kandil OM, Yang* Y, Song* H, Zheng* Y. Comparative characterization of microRNA-71 of Echinococcus granulosus exosomes. Parasite. 2023;30:55.

13. Chen M, Ren G, Zhang X, Yang L, Ding Q, Sun J, Xia J, Xu J, Jiang L, Fang W, Cheng* C, Song* H. DegU-mediated suppression of carbohydrate uptake in Listeria monocytogenes increases adaptation to oxidative stress. Appl Environ Microbiol. 2023 Oct 31;89(10):e0101723.

14. Wang N, Li P, Cheng Y, Song* H, Xu*C. Stem-loop structures control mRNA processing of the cellulosomal cip-cel operon in Ruminiclostridium cellulolyticum. Biotechnol Biofuels Bioprod. 2023 Jun 29;16(1):106

15. Xia J, Luo Y, Chen M, Liu Y, Wang Z, Deng S, Xu J, Han Y, Sun J, Jiang L, Song* H, Cheng *C. Characterization of a DsbA family protein reveals its crucial role in oxidative stress tolerance of Listeria monocytogenes. Microbiol Spectr. 2023 Dec 12;11(6):e0306023.

16. Chen M, Zhang J, Xia J, Sun J, Zhang X, Xu J, Deng S, Han Y, Jiang L, Song* H, Cheng* C. Listeria monocytogenes GshF contributes to oxidative stress tolerance via regulation of the phosphoenolpyruvate-carbohydrate phosphotransferase system. Microbiol Spectr. 2023 Sep 5;11(5):e0236523.

17. Li Y, Song J, Jiang S, Yang Y, Han Y, Zhong L, Zhou J, Wang M, Song* H, Xu* Y. Canine distemper virus (CDV)-neutralizing activities of an anti-CDV canine-derived single-chain variable antibody fragment 4-15 (scFv 4-15) screened by phage display technology. Int J Biol Macromol. 2024;257(Pt 2):128645.

18. Zhou Y, Zhang Y, Dong W, Gan S, Du J, Zhou X, Fang W, Wang* X, Song* H. Porcine epidemic diarrhea virus activates PERK-ROS axis to benefit its replication in Vero E6 cells. Vet Res. 2023 Feb 3;54(1):9.

19. Zhao J, Zhang R, Wang W, Jiang S, Liang H, Guo C, Qi J, Zeng* H, Song* H. Low-dose ketamine inhibits neuronal apoptosis and neuroinflammation in PC12 cells via α7nAChR mediated TLR4/MAPK/NF-κB signaling pathway. Int Immunopharmacol. 2023 Apr;117:109880

20. Han Y, Luo P, Zeng H, Wang P, Xu J, Chen P, Chen X, Chen Y, Cao Q, Zhai R, Xia J, Deng S, Cheng A, Cheng* C, Song* H. The effect of O-antigen length determinant wzz on the immunogenicity of Salmonella Typhimurium for Escherichia coli O2 O-polysaccharides delivery. Vet Res. 2023 Feb 27;54(1):15

21. Sun Y, Kou Y, He X, Yan Y, Guo X, Yang X, He N, Cho WC, Kutyrev I, Harandi MF, Kandil OM, Wang* X, Song* H, Zheng* Y. Efficient delivery of Echinococcus multilocularis miRNAs using chitosan nanoparticles. Biomed Pharmacother. 2022 150:112945.

22. Shao C, Yu Z, Luo T, Zhou B, Song Q, Li Z, Yu X, Jiang S, Zhou Y, Dong W, Zhou X, Wang* X, and Song* H (2022). Chitosan-Coated Selenium Nanoparticles Attenuate PRRSV Replication and ROS/JNK-Mediated Apoptosis in vitro. Int J Nanomedicine 17, 3043-3054.

23. Gao X, Sun X, Yao X, Wang Y, Li Y, Jiang X, Han Y, Zhong L, Wang* L, Song* H, and Xu* Y (2022). Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host Cells. J Virol, e0111322.

24. Zhou Y, Zhou X, Dong W, Zhang Y, Du J, Zhou X, Fang W, Wang* X, and Song* H (2022). Porcine circovirus type 2 induces CHOP-ERO1alpha-ROS-mediated apoptosis in PK-15 cells. Vet Microbiol 273, 109548.

25. Han Y , Luo P, Chen Y, Xu J, Sun J, Guan C, Wang P, Chen M, Zhang X, Zhu Y, Zhu T, Zhai R, Cheng* C, Song* H. Regulated delayed attenuation improves vaccine efficacy in preventing infection from avian pathogenic Escherichia coli O78 and Salmonella Typhimurium. Veterinary Microbiology, 2021, 254:109012

26. Cheng C, Han X, Xu J, Sun J, Li K, Han Y, Chen M, Song* H. YjbH mediates the oxidative stress response and infection by regulating SpxA1 and the phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) in Listeria monocytogenes. Gut Microbes, 2021;13(1):1-19.

27. Yang Y, Xu P, He P, Shi F, Tang Y, Guan C, Zeng H, Zhou Y, Song Q, Zhou B, Jiang S, Shao C, Sun J, Yang Y, Wang X, Song* H. Mycobacterial PPE13 activates inflammasome by interacting with the NATCH and LRR domains of NLRP3. FASEB J. 2020,34:12820-12833

28. Zhou Y, Chen L, Zhang L, Shao C, Sun J, Jiang S, Song Q, Zhou B, Yang Y, Dong W, Yang Y, Wei F, Fang W, Wang* X, Song* H. Simultaneous Identification of 6 Pathogens Causing Porcine Reproductive Failure by Using Multiplex Ligation-Dependent Probe Amplification. Transbound Emerg Dis. 2020;67:2467-2474

29. Zhang X, Guan C, Hang Y, Liu F, Sun J, Yu H, Gan L, Zeng H, Zhu Y, Chen Z, Song* H, Cheng* C. An M29 aminopeptidase from Listeria monocytogenes contributes to in vitro bacterial growth but not to intracellular infection, Microorganisms, 2020, 8(1). pii: E110

30. Sun J, Hang Y, Han Y, Zhang X, Gan L, Cai C, Chen Z, Yang Y, Song Q, Shao C, Yang Y, Zhou Y, Wang X, Cheng* C, Song* H. Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes. Virulence. 2019,10(1):910-924

31. Zhang Y, Yao Y, Qiu X, Wang G, Hu Z, Chen S, Wu Z, Yuan N, Gao H, Wang J, Song H, Girardin SE, Qian* Y. Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing. Nat Immunol. 2019,20(4):433-446  

32. Yang Y, Wang H, Kouadir M, Song* H, Shi* F. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 2019,10(2):128  

33. Zhang X, Wang Z, Fang Y, Sun R, Cao T, Paudyal N, Fang W, Song* H. Antibody microarray immunoassay for simultaneous quantification of multiple mycotoxins in corn samples. Toxins (Basel). 2018;10(10). E415  

34. Zhang X, Wang Z, Xie H, Sun R, Cao T, Paudyal N, Fang W, Song* H. Development of a magnetic nanoparticles-based screen-pPrinted electrodes (MNPs-SPEs) biosensor for the quantification of ochratoxin A in cereal and feed samples. Toxins (Basel). 2018 10(8). E317

35. Sun J, Li Q, Shao C, Ma Y, He H, Jiang S, Zhou Y, Wu Y, Ba S, Shi L, Fang W, Wang* X, Song* H, Isolation and characterization of Chinese porcine epidemic diarrhea virus with novel mutations and deletions in the S gene, Veterinary Microbiology, 2018, 221, 81-89

36. Quan C, Shi W, Yang Y, Yang Y, Liu X, Xu W, Li H, Li J, Wang Q, Tong Z, Wong G, Zhang C, Ma S, Ma Z, Fu G, Zhang Z, Huang Y, Song H, Yang L, Liu WJ, Liu Y, Liu W, Gao* GF, Bi* Y. New threats from H7N9 influenza virus: spread and evolution of high- and low-pathogenicity variants with high genomic diversity in wave five. J Virol. 2018, 92(11), e00301-18    

37. Wang X, Shao C, Wang L, Li Q, Song* H, Fang* W. The viral non-structural protein 1 alpha (Nsp1) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells. Vet Microbiol. 2016, 84:73-79  

38. Ma Y, Zhang Y, Liang X, Oglesbee M, Krakowka S, Niehaus A, Wang G, Jia A, Song H, Li* J, Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus. Veterinary Microbiology, 2016(186): 90-96

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